Biography:

Hari Shanker Sharma is the Director of Research (International Experimental Central Nervous System Injury & Repair, IECNSIR) at University Hospital; Uppsala University and  is a Professor of Neurobiology (MRC), Docent in Neuroanatomy (UU) and is currently affiliated with Department of Surgical Sciences, Division of Anesthesiology and Intensive Care Medicine, Uppsala University, Sweden.

Hari Sharma after carrying out a series of Government of India funded Research Projects on the BBB and brain dysfunction joined the lab of Neuropathology at Uppsala University with Professor Yngve Olsson in 1988 to investigate passage of tracer transport across the BBB caused by stress or traumatic insults to the Brain and Spinal cord at light and electron microscopy.

On his work on hyperthermia Dr. Sharma received the prestigious Neuroanatomy award “Rönnows Research prize” of Uppsala University for “best neuroanatomical research of the year 1996” followed by the  Best Thesis Award of the Medical faculty, “The Hwassers Prize” of 1999.

Dr. Sharma also earned the prestigious title of “Docent in Neuroanatomy” of Medical Faculty, Uppsala University in April 2004.

His recent work on 5-HT3 receptor mediated neuroprotection in morphine withdrawal induced neurotoxicity won the coveted prize of Best Investigator Award 2008 and Best Scientific Presentation by European Federation of the International Association for Study of Pain (ISAP).

Dr. Sharma’s work over 30 years on the blood-brain barrier and brain edema won him the US Neurosurgeon Dr. Anthony Marmarou Award (2011) by the International Brain Edema Society at their 15th Congress in Tokyo, Japan.

Dr Sharma was decorated with the most prestigious “Hind Rattan Award 2012” (Jewel of India) and Mahatma Gandhi Pravasi Gold Medal at House of Lords, London, UK.

He was also awarded with one of the coveted “Bharat Jyoti Award 2013” (Glory of India)  and Navrattan Award 2013” (Nine Jewels of India) Singh, in New Delhi, India.

Hari Sharma is the Founding President of the Global College of Neuroprotection & Neuroregeneration (2004-); Elected President of International Association of Neurorestoratology (IANR) (2014-); and selected Senior Expert of Asia-Pacific CEO Association, Worldwide (APCEO) (2012-) for his contribution to uplift scientific research in many countries Globally that may have better economic and social benefit for the mankind.

Abstract:

Timing: 11:50-12:25 CEST 

Military personnel are often prone to traumatic brain injury (TBI) that enhances the possibility of Alzheimer’s disease (AD) at a later stage. Since TBI leads to breakdown of the blood-brain barrier (BBB) and extravasation of serum proteins into the brain fluid compartment, it is quite likely that plasma amyloid beta protein (AbP) may enter into the brain after TBI leading to development of AD. Thus, there is a need to understand the role of TBI in AD. AD like brain pathology was induced by intracerebroventricular (i.c.v.) administration of soluble form of AbP 200 ng/30 µl per day into the left lateral ventricle for 4 weeks in a rat model. This treatment resulted in AD like pathology e.g., deposit of AbP in the brain as well as BBB breakdown, edema formation and neuronal, glial and axonal injuries. In order to find out role of TBI in AD development, rats were subjected to mild concussive head injury (CHI) by dropping a weight of 114.6 g over the exposed parietal skull bone from a 20 cm height through a guide tube. This adjustment resulted in an impact of 0.224 N over the skull surface. In these CHI inflicted animals AbP was infused in identical conditions starting from 1 week after injury for 4 weeks. Our observations show that AbP infusion in CHI rats exacerbated BBB breakdown to serum proteins by 2-4 fold, edema formation by 1.5 to 2 fold and marked increase in neuronal, glial or axonal injuries as compared to AbP treatment in normal animals. Immunohistochemical examination revealed enhanced deposits of AbP in the brain in CHI group after AbP infusion. The glial reactions and myelin damages were also much more aggravated. Extravasation fo albumin was also increased in several brain regions in CHI group after AbP infusion as compared to normal animals. Administration of mesenchymal stem cells (MSCs, ca. 1 million, i.c.v.) 1 week after AbP infusion resulted in marked neuroprotection as seen by reduced BBB leakage, AbP deposits and brain pathology in normal animals. Likewise i.c.v. administration of 50 µl cerebrolysin daily for 3 weeks starting from 1 week after AbP infusion was neuroprotective in normal animals. However, in CHI group these treatments either alone or in combination were ineffective. Interestingly when TiO2 nanowired MSCs and cerebrolysin administered together in identical conations, significant neuroprotection was achieved in AD cases in CHI group. Taken together, our observations are the first to point out that co-administration of MSCs and cerebrolysin using nanowired delivery has far more superior neuroprotective effects in AD model in CHI, not reported earlier.

Biography:

MS degree (Quantum Radiophysics), Kiev National Shevchenko University (KNShU),
1969;  Ph.D. (Theoretical Physics), Bogolyubov Institute for Theoretical Physics, Kiev, 1975;
Doctor Habilitus degree (DSci) (Theoretical Physics and Solid State Physics) KNShU, 1992.
Since 2007 Vladimir Vysotskii is Head of Theoretical Radiophysics Department at KNShU.

Scientific research:  modern problems of radiobiology and biophysics; modern problems of nuclear physics: low energy nuclear reactions; conrolled nuclear decay; etc.

Prof.Vladimir Vysotskii has published more 400 papers in reputed journals and 12 scientific monographs (USA, Japan, Ukraine, Russia, India, Elsevier, World Scientific Publ.

Abstract:

Timing: 17:05-17:30 CEST

All traditional conservative methods of treatment and prophylaxis in medicine involve the use of biochemical processes with the introduction of different drugs in the human body. Such an indirect (secondary) method has many drawbacks associated with transportation to the desired organ, adaptation and competition of foreign chemical elements and their compositions.

In contrast to this indirect method of treatment we predicted and realized the method of creation of necessary chemical elements and isotopes in the necessary vital organ by safe controlled nuclear reactions . In particular, we have realized the safe formation of the necessary macro and microelements (e.g. various iron isotopes Mn55+d=Fe57, Na23+P31=Fe54 etc) and destruction of very dangerous radioactive isotopes (e.g. Cs137+p=Ba138) in growing biological systems. Using similar technology, other chemical elements and isotopes can be created without concomitant gamma-radiation and radioactive isotopes formation. These processes of safe nuclear transmutation can efficiently proceed in living organisms based on the exact laws of nuclear physics and quantum mechanics due to the formation of coherent correlated states of interacting particles. These nuclear transmutations, unlike very dangerous processes in nuclear reactors and accelerators, are stimulated by the topological features of cell division and DNA replication and occur at the natural temperature of the human body.

In the future, these processes can be used for the selective destruction of cancer cells.

These nuclear processes explain many mysterious phenomena in medicine (e.g. accelerated tooth decay may be associated with a nuclear reaction Ti+Ca=Mo in the oral cavity conducted with participation of natural saliva microorganisms and Ti and Ca isotopes when using traditional titanium implants).

These total safe targeted nuclear reactions are fundamentally different from "standard" nuclear physics and can be used in many applications (nano-medicina, nano-biotechnology, for production of rare isotopes and destruction of harmful elements ets).

Biography:

Mykhaylo Vysotskyy has graduated from the Department of Radiophysics, Taras Shevchenko National University of Kyiv in 2007. Since that time, he was post-graduate student (2007-2010, Ph.D. in Theoretical physics, 2011) and works at the same Department as an assistant (2010-2017) and associate professor (2017-present). His main scientific interests are charged and neutral particles interaction with oriented media for the purposes of nanoscience, formation of coherent correlated states and their influence of particles interaction, application of coherent correlated states for different problems. He has 38 articles in Scopus and his h-index is 9. He has an award of the Parlament of Ukraine to the most talented young scientists in the field of fundamental and applied researches and scientific and technical developments.

Abstract:

The traditional method of processing semiconductor materials and other surface objects involves exposure to focused particle beams. Moreover, each of the particles is described by space-limited Gaussian wave packets. They can be characterized by wave function

initial structure and initial spatial width  Such packets have constant velocity , momentum  and energy  During their space-time evolution synchronous decrease of amplitude and widening of the spatial width  occur (Fig., upper row). These packets correspond to uncorrelated states of particles. Its application for precision nanotechnology is ineffective due to the rapid spatial “spreading” and the inability to focus.

For application in nanotechnology coherent correlated packets (CCP) with initial wave function are more efficient.

Such packets are characterized by correlation coefficient  The space-time evolution of CCP is shown in the Fig. (lower row). The motion of a CCP leads to its spatial collapse at the time  in area . If [1-5], this collapse is characterized by a significant decrease of the packet width from the initial value  to a minimum value . Immediately after the collapse area the amplitude of wave packet decreases quickly.

Another important feature of CCP is an increase of particle energy fluctuations from the initial value  at  up to a  at  

For example, if the proton is represented as a wave packet with a longitudinal size  in the uncorrelated state the energy fluctuation of such moving packet is limited to  In the correlated state with  [1-5] fluctuation increases to  Such energy greatly exceeds the average energy eV of proton longitudinal motion in typical particle nanotechnology systems. In this case we have a unique combination of parameters of each particle of the beam: it interacts with a given object (e.g. its surface) only in a precisely defined place and in the process of such interaction it is able to perform necessary action that corresponds to a very large energy. Before this area and behind it there is no such effect. These features allow the use CCP for a targeted localized action.

The report also presents possible methods for the formation of slow particles correlated states. 

Biography:

Abstract:

Timing: 12:25-12:50 CEST

Sleep deprivation (SD) is common in military personnel engaged in combat operations. Our previous reports show that 12 h SD alone induces brain pathology and continued until 72 h in a progressive manner. However, these military personnel with SD are also prone to traumatic brain injury (TBI). Thus, a possibility exists that TBI could further exacerbate SD induced brain pathology. Several lines of evidences suggest that both in TBI and in SD a decrease in alpha-melanocyte stimulating hormone (MSH) and brain derived neurotrophic factor (BDNF) levels occur in plasma as well as in the brain. This could be one of the leading causes of brain pathology in SD or in TBI. Thus, exogenous supplement of alpha-MSH and/or BDNF could induce neuroprotection in SD or TBI. In present investigation effect of concussive head injury (CHI) in SD induced brain pathology and effects of alpha-MSH and neurotrophic factors treatment leading to neuroprotection in a rat model was examined. SD was induced in rats using the inverted flowerpot methods surrounded by water level 1 cm below the platform (6.5 cm in diameter) that allow free movement but continuously sleep leads to fell down in water disturbing the sleep process.  SD was induced in healthy rats as well as in rats that were subjected to CHI by dropping a weight of 114.6 g over the skull causing an impact of 0.224 N on the brain without skull fracture. Rats subjected to 48 h SD in CHI (24 h after insult) exhibited greater brain pathology e.g., higher leakage of Evans blue albumin and radioiodine ([131]-I) by 3-to 4 fold as compared to naïve rats subjected to identical SD. Neuronal, glial and axonal damages using histopathological techniques were also exacerbated by several fold in CHI after SD. Plasma alpha-MSH and BDNF level shows significant reduction (alpha-MSH 8.34±0.23 vs. Control 20.34±0.12 pg/ml; BDNF 8.23±0.11 vs. control 22.34±0.21 pg/ml) in SD group after CHI as compared to SD group alone (alpha-MSH 15.13±0.12 pg/ml; BDNF 14.23±0.08 pg/ml). Intravenous administration of alpha-MSH (100 µg/kg) together with cerebrolysin (a balanced composition of several neurotrophic factors and active peptide fragments 5 ml/kg) significantly induced neuroprotection in CHI or SD groups alone. However, TiO2 nanowired delivery of alpha-MSH and cerebrolysin is needed to induce neuroprotection in SD rats after CHI. The levels of alpha-MSH and BDNF were also retired by this treatment in SD rats after CHI (alpha MSH 22.34±0.12 pg/ml; BDNF 23.34±0.17 pg/ml). Taken together our results are the first to point out that TiO2 nanowired administration of alpha-MSH and cerebrolysin induces superior neuroprotective effects following SD in CHI, not reported earlier.

Biography:

Ravi Shankar Kumar is a PhD Scholar at Enhanced Oil Recovery (EOR) Laboratory (Department of Petroleum engineering and Geological Sciences)at Rajiv Gandhi Institute of Petroleum Technology, India (Institute of National Importance) under the Ministry of Petroleum &Natural Gas, Govt. of India. He is working under Dr. Tushar Sharma on Chemical based EOR techniques, Nanofluid Design, CO₂ stabilized foam flooding, Carbon Capturing (Trapping), Rheology of polymer-based nano-fluids, CO₂ trapping, Nano-assisted EOR, etc

Vision: His vision is to explore new areas of science and technology in the field of Oil and Gas recovery process to further diversify global energy basket to meet the current and future challenges of Oil and Gas development.

Abstract:

Timing: 17:30-17:55 CEST 

The increased demand of hydrocarbon enforces reduction in oil reserves globally which became one of the major challenge for the world. Thusly, improving oil production from current reservoirs holds the key to meet the current and near future challenges of global energy demands. The development of new technologies such as nanotechnologies showed potential benefits to address energy challenges for several industrial applications including oilfield. Silica Nanofluid, a colloidal solution of solid charged silica (SiO₂) nanoparticles (NPs) suspended in a base fluid (oil/water/glycol/polymeric solutions); possibly beneficial to improve the oil production by governing the matter of facts at nano scale level. However, uniform distribution of NPs within the nanofluid (stable nanofluid) significantly improves the oil recovery due to large exposed surfaces; remarkably able to modify reservoir rock/fluid properties such as wettability of reservoir rock/interfacial tension (IFT) between oil and nanofluid. Therefore, the first requisite for nano-assisted oil recovery (N-EOR) is attributed to the stability of nanofluid and secondly, the impact of stable nanofluids on reservoir properties since flowing through porous media. However, stability of any nanofluid can be influenced by reservoir conditions such as high temperature, high salinity which may reduce oil production in N-EOR process.

In this regard, silica nanofluids were prepared using deionized (DI) water and found unsuccessful due to rapid agglomeration of NPs in results showed severe sedimentation. Thusly, a typical oilfield polymer polyacrylamide (PAM) were utilized as base fluid (1000 ppm PAM solution) to render the effect of NPs agglomerations. PAM also provides suitable viscosity contrast to displace the oil in porous media through providing stable rheological properties. However, harsh reservoir conditions such as temperature and salinity limits the applicability of nanofluid and makes them a conventional fluid. Thusly, another similar charged and thermally stable NPs (TiO₂) were included in the silica nanofluid to curtail the effect of temperature for harsh reservoirs. In the other hand, anionic surfactant were included to the silica nanofluid to render the effect of silica nanofluid in high saline reservoirs. Additionally, the surfactant forms micelles at critical micelles concentration (CMC) which is capable to reduce the IFT between oil/nanofluid and great impact to enhance the oil production. Moreover, stability of the formulated nanofluids were characterized for stability using macroscopic study, dynamic light scattering (DLS) study, ultraviolet–visible (UV-vis) spectroscopy, scanning electron microscopy (SEM) with elemental analysis and mapping techniques followed by rheological study; and investigated for oil recovery in harsh reservoirs (high temperature and high salinity). Before, oil recovery experiments, the reservoir properties such as wettability alteration and IFT reduction were investigated. Generally, the NPs get absorbed on the reservoir rock surfaces and help to alter the wettability form oil wet to water wet favorable for high oil recovery. The obtained results showed that the surface coated NPs by surfactant and super molecular structure of SiO₂óTiO₂ nanocomposites provides a stable nanofluid of superior capability by maintaining uniform distribution is interesting to avoid early particle aggregation thusly showed incremental oil recovery of more than 70%. This article discusses the novel fabrication methodology of a stable nanofluid using colloidal aspects for subsurface oilfield applications where formations conditions becomes a major challenge during flow through porous and permeable media; would be fortune made for N-EOR in harsh reservoirs. Therefore, this study devoted to the fundamental aspects of stabilizing silica nanofluid and their implications in porous media for oil recovery applications.

Biography:

Irene Russo Krauss took her degree in Chemistry and PhD in Physical Chemistry focusing her research activities on structural characterization of biological macromolecules and their complexes, by means of crystallographic and spectroscopic techniques. In the last years, she enlarged her research interests working with different kind of nanosystems to be used in medical applications, including metal-based nanoparticles and liposomes, and studying their behavior with respect to biological components, using a combination of scattering and spectroscopic techniques.

Abstract:

Timing: 12:50-13:15 CEST

Nanoparticles (NPs) are increasingly exploited as diagnostic and therapeutic devices in medicine. Among them, superparamagnetic nanoparticles (SPIONs) represent very promising tools for magnetic resonance imaging, local heaters for hyperthermia and nanoplatforms for multimodal imaging and theranostic.1 However, the use of NPs, including SPIONs, in medicine present several issues, first of all the encounter with the biological world and proteins in particular. Indeed, nanoparticles can suffer from protein adsorption, which can affect NP functionality and biocompatibility.2 In this respect we have developed small Fe3O4 NPs coated with a double layer of oleic acid/oleylamine and 1-octadecyl-2-hydroxy-sn-glycero-3-phosphocholine (18LPC),3 which can be further functionalized employing drugs4 or different targeting5 or diagnostic agents bearing a proper hydrophobic tail, and we have investigated their interaction with two abundant human plasma proteins, human serum albumin (HSA) and human transferrin. By means of spectroscopic and scattering techniques, we analysed the effect of SPIONs on protein structure and the binding process. We structurally characterized HSA/SPIONs complexes by means of light and neutron scattering, highlighting the formation of a monolayer of protein molecules on NP surface. By investigating their interaction with lipid bilayers mimicking biological membranes, we show that HSA/SPIONs do not affect lipid bilayer features and could be further exploited as nanoplatform for future applications

Biography:

Dr. Annalisa Calò has expertise in micro- and nanoscale surface fabrication and characterization techniques. She graduated in Chemistry at University of Bologna and did her PhD at the Institute for the Study of Nanostructured Materials (ISMN-CNR, Bologna, Italy) in 2010. She spent her postdocs in Spain (Institute for Bioengineering of Catalonia IBEC, Catalan Institute of Nanotechnology ICN2 and CIC nanoGUNE) where she worked on the nanoscale characterization of different materials and surfaces (nanovesicles for drug delivery, virus particles, nanoscale wetting of inorganic crystals). In 2016 she moved to New York, where she specialized in thermal scanning probe lithography for the patterning of 2D materials and polymer films (Advanced Science Research Center ASRC-CUNY) and in the development of AFM for biomedical research (imaging, mechanobiology) (Memorial Sloan Kettering Cancer Center MSKCC). She is author of 25 publication in indexed journals.

Abstract:

Timing: 13:15-13:40 CEST

Two-dimensional transition metal dichalcogenides show great potential as a new class of atomically thin semiconductors for electronics and optoelectronics. Understanding the atomistic origin of defects in these materials and their impact on the electronic properties, as well as finding viable ways to dope them is matter of intense scientific and technological interest. In particular, controlling defects could be envisioned as a strategy for the design of ad-hoc electronic and optoelectronic properties. Here, we demonstrate a new integration of thermochemical scanning probe lithography (tc-SPL) with a flow-through reactive gas cell to achieve a nanoscale control of the local thermal activation of defects in monolayer MoS2. The tc-SPL activated nanopatterns can present either p- or n-type doping on demand, depending on the used gasses, allowing the realization of field effect transistors, and p-n junctions with precise sub-?m spatial control and a rectification ratio over 104. Doping and defects formation mechanisms are elucidated at the molecular level by means of X-Ray photoelectron spectroscopy, scanning transmission electron microscopy, and density functional theory. The p-type doping of locally heated MoS2 in HCl/H2O atmosphere is found to be related to the rearrangement of sulfur atoms and the formation of new protruding covalent S-S bonds on the surface, which produce a band structure with p-character. Alternatively, local heating MoS2 in N2 produces n-character.

Biography:

Dr. Radhamanohar Aepuru is an assistant professor in mechanical engineering department, Universidad Tecnológica Metropolitana, Santiago, Chile. Aepuru’s current research is funded by FONDECYT Project No: 3180172, Chile. His expertise is in development of multifunctional nanostructures and investigation of carrier dynamics for fabrication of optoelectronic and electromechanical devices such as photodetectors and energy harvesters.

Abstract:

Timing: 16:40-17:05 CEST

Inorganic hybrid nanostructure based electronic devices have drawn potential interest and provide significant new insights to develop energy conversion and storage devices such as photodetectors and energy harvesters. The strong light-matter interactions in novel organic−inorganic nanostructures especially metal oxide/metal halide perovskites nanocomposites have explored to realize photonics and optoelectronics devices with impressive performance achieved by tuning the optical/electrical properties. In this work, we discuss the development of novel composite nanostructures as functional optoelectronic devices with superior electro-optic sensitivity. The detailed spectroscopic characterizations were studied to reveal the carrier relaxation and charge transfer dynamics in the perovskites nanocomposites using time resolved luminescence and broadband dielectric spectroscopy. The induced dielectric polarization in the nanocomposites exhibited strong electrical conduction and showed anomalous dielectric behavior at the percolation threshold concentration due to the large resonance derived from the plasmoic oscillations of delocalized charges. An optoelectronic system integrated with nanocomposite is demonstrated to know the electro-optic sensitivity. The developed composite nanostructures exhibit significant optical and electrical properties, which have wide potential applications in various MEMS/NEMS devices such as photodetectors and nanogenerators.

Biography:

Will be updated soon

Abstract:

Recent research in the field of phosphors and scintillatorsforradiation detectors for medical, industrial and scientific imaging and further development and exploitation of powerful X-ray sources such as e.g. synchrotron radiation. Thus, an intense research and development continues to explore new phosphor and scintillation materials or the optimization of the current ones taking advantage of new technological methods fortheir preparation.Nanocrystalline Gd₂O₃S scintillator with structures were successfully synthesized through precipitation process and subsequent calcination for X-ray imaging detectors. In this work, a simple precipitation process was carried out using diethanolamine as a precipitant to prepare nanocrystalline Erdoped Gd₂O₃. Scintillation properties such as luminescent spectra, light intensity and decay time were measured for the synthesized powder. The sample calcined at 400-900^oC showed the highest light intensity. The scintillator emitted a strong red light at near 610nm under photo and X-Ray luminescence for its potential X-Ray imaging detector applications.

Biography:

Jamal Davoodi was born on December 1, 1969, in Iran, He studied physics at Isfahan University and now he is professor of physics at university of Zanjan.Jamal Davoodi has expertise in investigation of thermal and mechanical properties of nano-structures, especially carbon nano-structures. He is interested in to molecular dynamics simulation technique to study properties of nano materials. This method is very helpful for scientists which investigate on basic science.

Abstract:

Timing: 18:45-19:10 CEST 

Boron is capable of forming a large number of allotropes, except a few significant three-dimensional phases that can form zero-dimensional (0D), one-dimensional (1D), and two-dimensional (2D) clusters [1]. Two-dimensional boron allotrope (borophene) is synthesized under extremely vacuum conditions on the silver surface, which has unique mechanical and thermal properties [2]. The crystalline structure of borophene can be represented by the lattice parameters a, b, and the height h (Fig. 1). Despite promising applications of borophene, studies of its thermal properties are still minimal. In general, the exact phase transition temperature for the borophene sheets has not been reported. In this study, molecular dynamics simulation of the borophene phase transition has been investigated using the Large-scale Atomic/Molecular Massively Parallel Simulator (LAMMPS) package.  The ReaxFF force field has been used to model atomic interactions in borophene sheets [3]. The structure was relaxed by the Nose-Hoover thermostat and Berendson barostat (NPT) after 50 ps. The periodic boundary condition used to keep the number of particles constant. The variation of cohesive energy and mean square displacement of borophene calculated to detect phase transition temperature. The phase transition temperature obtained 2057K. A comparison of the results shows that the both quantitieshave generated the same value

Biography:

Dr. hab. eng. Miroslaw Kwiatkowski in 2004 obtained Ph.D. degree at the AGH University of Science and Technology in Krakow (Poland), and in 2018 D.Sc. degree at the Wroc?aw University of Technology (Poland). Currently Dr. Miros?aw Kwiatkowski is working an assistant professor at the AGH-UST. His published work includes more than 45 papers in reputable international journals and 100 conference proceedings. He is the editor in chief of The International Journal of System Modeling and Simulation (United Arab Emirates), an associate editor of Micro & Nano Letters Journal (United Kingdom) and a member of the organizing committees many conferences in Europe, Asia and USA, as well as a regular reviewer in a reputable scientific journals.Dr. hab. eng. Miros?aw Kwiatkowski in 2004 obtained Ph.D. degree at the AGH University of Science and Technology in Krakow (Poland), and in 2018 D.Sc. degree at the Wroc?aw University of Technology (Poland). Currently Dr. Miros?aw Kwiatkowski is working an assistant professor at the AGH-UST. His published work includes more than 45 papers in reputable international journals and 100 conference proceedings. He is the editor in chief of The International Journal of System Modeling and Simulation (United Arab Emirates), an associate editor of Micro & Nano Letters Journal (United Kingdom) and a member of the organizing committees many conferences in Europe, Asia and USA, as well as a regular reviewer in a reputable scientific journals.

Abstract:

Timing: 13:40-14:05 CEST 

The activated carbons and the adsorption processes taking place on their surface have been the object of widespread research and application. In particular these materials are used to rid the air of substances that are harmful to human health, including for protection from poisonous substances and for environmental protection in the processes of removing harmful substances from waste gases. The porous structure and functional properties of the activated carbons are  dependent on the structure of the original raw material. As a consequence, the choice of suitable material is no less important than the selection of adequate production method and the determination of optimum process conditions. Therefore, a search for new raw materials that would be useful in the production of the activated carbons has been under way, and particular attention has been paid in this regard to biomass waste from food and timber industries and agriculture. This work presents the results of an analysis of the impact of the activator to the carbonization product mass ratio on the porous structure of activated carbons prepared from various woods by carbonization and chemical activation with potassium hydroxide. The analyses suggest the significant potential of producing adsorbents characterized by a large surface area and adsorptive capacity from woods. Analysis of the shape of the adsorption energy distribution on the first layer determined on the basis of the adsorption nitrogen adsorption isotherm showed a narrow spectrum of sites with very high adsorption energy and a wide spectrum of low energy sites. The LBET method was particularly important in the conducted research, which allowed, among other things, to determine the degree of heterogeneity of the surface. Additionally, this method allowed to determine the shape of clusters of adsorbate molecules forming in the pores of the studied activated carbons, as well as to obtain information on the distribution of energy of adsorption of their surface. The LBET method was also the only one to determine the reliability and credibility of the obtained analysis results. In conclusion, it should be stressed that the proper selection of conditions for the preparation of activated carbons, taking into account not only technical but also energy and economic aspects, is a factor determining the practical use of activated carbons in industrial technologies and everyday life.

Biography:

Will be updated shortly

Abstract:

Timing: 18:45-19:10  CEST

SmCo is a permanent magnetic material having peculiar characteristics. The SmCo Nanoparticles can be used in different application fields. SmCo nanoparticles could beused  for temperature treatments of the cancer in medicine. Hyperthermia method increases the local temperature in human body using magnetic fields. When a  cellular has one increase temperature in the range of 40°- 43°C we have cellular apoptosis. The number of cancer cells could be reduced and using chemioterapic treatment it is possibile obtained died cancer (1,2,3) .In this paper we present preliminary experimental resuls  and we discussed the Trasmission Electron Microscopy characterization  and the SmCo NPs thermic properties .

Biography:

Ratnesh Das is a Professor in the Department of Chemistry, Dr.Harisingh Gour Central University, Sagar, India.  He commands a rich experience in teaching, and research of about 16 years during which he has supervised many sponsored research projects. His active research areas include Heterocyclic synthesis, medicinal chemistry , electro-organic chemistry, synthesis of nano-catalysts and green chemistry. He has authored about 60 research papers in peer-reviewed national and international journals and refereed conferences organized by professional societies around the world. He is an active member of several professional bodies and societies, both in India and abroad. He is a vibrant speaker and delivered many lectures  in conferences, workshops, and seminars organized both in India and abroad.

Abstract:

Timing: 17:55-18:20 CEST 

The electrochemically functionalized multiwalled carbon nanotubes/copper nanoparticles (fMWCNT/CuNPs) carbon paste electrode (fMWCNT/CuNPs-CPE) was successfully modified by silver nanoparticles (AgNPs) via electrocatalytic process. The formation of modified electrode (AgNPs/fMWCNT/Cu NP-CPE) was observed by Field Emission Scanning Electron Microscopy and X-ray diffraction techniques. The as-prepared electrodes were explored for the trace recognition of calcium channel blocker drug amlodipine besylate (ADB) using cyclic voltammetry and electrochemical impedance spectroscopy measurements. Kinetic parameters like electron transfer coefficient (α), charge due to adsorption (Qads), surface coverage (Γ), charge transfer coefficient (Rct), and apparent electron-transfer rate constant (kapp) for the designed electrodes were evaluated. The nanoparticles based electrochemical sensor displayed high sensitivity, good selectivity and favorable catalytic ability for the oxidation of calcium channel blocker drug.

Biography:

Agnieszka Kolodziejczyk is a graduate at the Faculty of Physics, Astronomy and Applied Computer Science of the Jagiellonian University in Krakow(Poland). She was awarded M.Sc. degree in Medical Physics in 2009 and Ph.D. degree in Biophysics in 2013. Mrs. Kolodziejczyk in the framework of the master's thesis, doctoral dissertation, and national and foreign scientific internships, acquired experience in the use of atomic force microscopy and related techniques, as well as cell culture and fluorescence microscopy.

From 2014 she is the scientific researcher in the Nanomaterial Structural Research Laboratory in Bionanopark in Lodz (Poland). In Bionano park, she gained experience working with nanomaterials for cell culture, dynamic light scattering technique, confocal, and electron microscopies. Currently, she is the Project Manager funded by the National Science Centre entitled “The influence of selected nanoparticles on the elastic properties of endothelial cells evaluated using atomic force microscopy”. The researcher's main interest is the nanomechanics of cells and tissue for the development of nanomedicine and related sciences.

Abstract:

Poster:

Biography:

Aleksandra Zimon graduated at the Faculty of Chemistry ofthe Lodz University of Technology. She obtained a M.Sc. degree in Environmental Protection in 2010 andPh.D. degree in Chemical Technology in 2019. From 2015 she has been the scientific researcher in the Nanomaterial Structural Research Laboratory in Bionanopark in Lodz. In Bionanopark she is involved in the research on nanomaterials in cell cultures. Moreover, she investigate physical and chemical properties of various nanoparticles. Her activities is concerned on electron microscopy, fluorescent microscopy,  dynamic light scatterings and spectroscopy technique.

The researcher's main interest is microscopy and spectroscopy analyses of different areas in the range of physical, biological, material and medical sciences.

Abstract:

Timing: 15:20-15:35 CEST

Statement of the Problem: Silver nanoparticles (SNPs) are used in a various commercial application in food, pharmaceutical, textile, electronics and chemical industries.It is important to select appropriate for applicationnanoparticles and thoroughinvestigatetheir chemical and physical properties. Proper sterilization ofnanoparticles is a very important step in biological application in cell culture.

Methodology & Theoretical Orientation: Effectof selected sterilization methods on silver nanoparticles was investigated using transmission electron microscopy (TEM), atomic force microscopy (AFM) and dynamic light scattering (DLS). Water suspension of silver nanoparticles wassubjected to autoclavingandsonication processes, and toxicity of these nanoparticles towardsendothelial cellswas determined withtetrazolium salt reduction tests (XTT).

Findings:Autoclaving process can form SNP aggregates. Sonication method can disintegrate aggregates of nanoparticles, but after the autoclaving process it becomesimpossible. The hydrodynamic radius distribution of SNPs obtained from DLS measurements confirm the occurrence of aggregation in autoclaved suspension. Similar results were observed on the TEM images andAFM measurementswhereSNPs had diameters from 70 to 120 nm, which is consistent with  DLS results.

XTT cell viability test was performed to investigate the effects of sterilization methods of SNP on cell viability

The value of absorbance obtained for the cell treated with SNPs in cell medium after autoclaving were higher than the absorbance for control sample – cells without SNPs. It could falsely suggest that the cell viability for this treated cell is higher than for control sample. High value of absorbance is related to the reduction of the tetrazole salt with the autoclaved cell medium and it not reflect veritable cell viability. Viability of cells exposed to sonicated SNPs is lower that for control sample and it amounts to 83% compared to control sample.

Our result clearly show XTT method’s limitation to cell viability measurements with SNPs in cell medium with phenol red after autoclaving.

Presented results are the part of the project fundedby The National Science Centre, agreement no. 2017/26/D/ST4/00918.

Poster:

Biography:

 Divya Vennu is currently purusing Masters in Electrical Engineering Universidad de Concepcion, Chile. Her expertise is in development of flexible polymer nanocomposites and investigation of electrical and electromechanical properties. Her research is intended to develop flexible capacitive pressure sensors and to utilize them in Biomedical applications

Abstract:

Timing: 15:50-16:05 CEST

The demand of flexible electronic devices led the scientific community to develop novel electroactive materials for various sensing devices to realize them in the potential applications in health monitoring, robotics, electronic skin and diagnostics. Especially, monitoring the human activities using integrated sensors are dedicated to non/invasive measurements such as pressure and force are seen in wide applications. Most of the sensing mechanisms are piezoresistive, piezoelectric and capacitive type. Among these, Capacitive pressure sensing technique gains more importance in biomedical application due to its low power consumption, high sensitivity, repeatable dynamic response and are relatively less prone to temperature and humidity changes.

Currently, capacitive sensors with high sensitivity are realized in prosthetics, humanoids, structural health monitoring, biomedical and plantar pressure monitoring in neurogenerative pathology applications. Materials for flexible capacitive sensors generally consist of electroactive polymers and ceramics as dielectric layer. Polymers such as poly(dimethylsiloxane), polyimide, polyvinylidene fluoride and its copolymers are widely used which are flexible, robust and have low dielectric properties. On the other hand, ceramics (such as BaTiO3, PZT, ZnO etc ) having high dielectric properties but are restricted for wide spread usage due to brittle and rigid in nature. To overcome this, polymer nanocomposite with synergetic properties of polymer matrix and ceramic nanofillers are realized for capacitive pressure sensors. In the present work, a high sensitive flexible nanocomposites is realized for piezo-capacitive pressure sensor. The detailed characterization of the nanocomposite is carried out through X-ray diffraction and transmission electron microscopy (TEM) studies. The electrical properties and electromechanical dynamic response are investigated using Impedance analyzer by measuring the change in capacitance under various load conditions. The developed flexible nanocomposite with superior electrical properties have wide potential applications for contact pressure monitoring in biomedical applications.

Poster:

Biography:

Idowu David Ibrahim has a bachelor’s and a master’s degree in Mechanical Engineering. He is currently finalizing his dual doctoral degree at the Tshwane University of Technology Pretoria South Africa and Université de Versailles Saint-Quentin-en-Yvelines France. He has worked on fibers and polymers to produce environmentally friendly and high strength nanocomposites. He has since published over fifty research articles. He is a member of the following professional bodies; South African Institution for Mechanical Engineering (SAIMechE), International Association of Advanced Materials (IAAM). He has acted as a reviewer for nine international journals. He is currently an Associate Editor for Global Journal of Engineering Sciences (GJES).His areas of research interest include fibers,engineering materials, nanotechnology, climate change, sustainable and renewable energy, control system, and manufacturing. He is currently working on smart materials for parabolic trough solar collectors and polymeric hot water storage tank.

Abstract:

Timing: 15:35-15:50 CEST 

Statement of the Problem: Polymer-based composites have attracted considerable interest in areas such as: automobile, construction, electronics, packaging and aviation industries [1]. Another important area where polymers have been widely used is in biomedical applications [2-3]. In clinical applications, the most widely used materials are the natural and modified natural materials. Other materials that have found useful applications are: metals, glass, ceramics, synthetic polymers and composites. This generation of materials are used due to their mechanical properties (high strength, toughness and ductility) [4].

Methodology & Theoretical Orientation: Sisal fiber was treated with 5% sodium hydroxide solution for ~2 hours in an oven at a temperature of 70^oC. The composites containing treated fibers at varying fiber contents (10, 20, 30 and 40 wt%) were prepared. The MAPP and nanoclaycontents were maintained at 5 wt% loading each for the composites.

Findings: The merits of polymers have greatly influenced the significant attraction that has been witnessed especially for biomedical applications. Basic properties, such as: superhydrophobicity, adhesion and self-healing exhibited by plants and animals have been mimicked in some polymer matrices and have found useful applications in biomedical.Fiber content had direct relationship with the tensile strength (TS) and tensile modulus (TM). As the fiber content increased, there was increase the TS and TM.Incorporation of nanoparticle alters the properties of the nanocomposites, therefore, extending the area of application.

Poster:

Biography:

Sujey Palma-Florez graduated as a pharmacist from the University of Chile in 2017. She worked for four years in several projects related to nanomedicine focused on nanocarriers based on metallic nanoparticles and extracellular vesicles. At the same time she worked as a research assistant at Advanced Center for Chronic Diseases (ACCDis) and at Institutional Program (PiDi), Chile. She carried out research on nanostructures for drug delivery, therapy and diagnosis for chronic diseases and microfluidic devices to study nanoparticle interactions. In 2019, she studied a Master's degree in Nanoscience at University of Barcelona (UB) and performed her master's thesis at the Institute for Bioengineering of Catalonia (IBEC), Spain, where she was developing a BBB-on-a-chip platform to evaluate the permeability of nanotherapeutic systems. In 2020, she worked in the company AINTECH, Chile using the benefits of copper nanoparticles as a tool against COVID-19 infection. Currently, she is starting her PhD in biomedicine at the UB.

Abstract:

Timing: 16:05-16:20 CEST 

Alzheimer’s disease (AD) is a chronic neurodegenerative disorder associated to the accumulation of toxic aggregates of amyloid β peptide (Aβ) in the brain that produce oxidative stress and neurotoxicity. Therefore, new molecules have being developed for AD’s treatment based on the disaggregation of Aβ cumulates. However, most of them do not reach the action site due the strict permeability in the brain by the blood brain barrier (BBB).
Nanotechnology is a cutting-edge field that extends different possibilities for the diagnosis and treatment of AD. In this direction, a nanosystem for AD treatment was reported that consists in gold nanorods (GNRs) functionalized with polyethylene glycol (PEG), a β sheet breaker peptide (D1) and a peptide to shuttling through the BBB (Angiopep-2). The results revealed that the GNRs-PEG-Ang2/D1 nanosystem inhibited Aβ growth in vitro and decreased the toxicity of Aβ aggregates in an in vivo model. Therefore, it is required to evaluate the permeability of those promising therapy agents quickly and easily. BBB-on-a-chip is an interesting platform due their versatile and lower cost design to mimic both in vivo physiological and pathological conditions for the study of drug permeability.
In this work, we synthetized and characterized GNR-PEG-Ang2/D1 by absorption spectrophotometry, dynamic light scattering, laser Doppler micro-electrophoresis and transmission electron microscopy. Then, BBB-on-a-chip device was fabricated consisting in a neural chamber with human astrocytes and pericytes and a lateral channel with human brain endothelial cells in order to mimic the BBB. We determined the cytotoxic effect of GNR-PEG-Ang2/D1 over the above mentioned cells. Finally, the permeability of the nanosystems was evaluated through the BBB-on-a-chip device by confocal microscopy. The results confirm that GNR-PEG-Ang2/D1 was successfully synthetized and functionalized with the peptide Angiopep-2 and D1. In addition, GNR-PEG-Ang2/D1 showed non-toxic effect for the tri-culture at the given range of concentration for 24 hours. BBB-in-a-chip results showed the development of tight junctions between the adjacent endothelial cells in the chip which are crucial for permeability assays. Lastly, GNRs permeability assay revealed differences between the chip control and the chip exposure to GNRs.

Figure 1. (A) Electron micrograph of GNRs-PEG-Ang2/D1 (B) Cell arrangement of tri-culture into BBB-on-a-chip.

Poster: